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Paris saponin VII (Chonglou Saponin VII) is a steroid saponin isolated from the roots and rhizomes of Trillium tschonoskii Maxim. Paris Saponin VII induced K562/ADR apoptosis was associated with inhibition of Akt/ P38 MAPK and P-GP. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins (Bax and cytochromic C), and decreases the protein expression levels of Bcl-2, caspase-9, Caspase-3, PARP-1, and P-Akt. Paris Saponin VII induces intense autophagy in K562/ADR cells and can be used in leukemia studies.
| Molecular Weight | 1031.18 |
| Formula | C51H82O21 |
| CAS Number | 68124-04-9 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[3] Bashir Ahmad, et al. Molecular mechanisms of anticancer activities of polyphyllin VII
[4] Chaoyi Zhong, et al. Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway
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