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Pardoprunox hydrochloride (DU-126891, SME-308) is an effective agonist of partial dopamine action, corresponding to pEC50 value 8.0. It is also a partial agonist inducing [35S]GTPγS binding, corresponding to pEC50 9.2 and serotonin 5-HT1A receptor 6.3.
| Molecular Weight | 269.73 |
| Formula | C12H16ClN3O2 |
| CAS Number | 269718-83-4 |
| Form | Solid |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related 5-HT Receptor Products |
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| Buspirone
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. |
| Clomipramine Hydrochloride
Clomipramine HCl is a hydrochloride salt of clomipramine which is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with Ki of 0.14, 54 and 3 nM, respectively. |
| Quetiapine Sulfone
Quetiapine Sulfone is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. |
| Quetiapine sulfoxide
Quetiapine sulfoxide is a 5-HT receptor agonist with a pEC50 value of 4.77 for human 5-HT1A. Quetiapine hemifumarate is a dopamine receptor antagonist with a pIC50 value of 6.33 for human D2. |
| Iloperidone
Iloperidone, a serotonin (5-HT2) receptor inhibitor, is used to study schizophrenia. |
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