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Pafuramidine

Cat. No. M28972

All AbMole products are for research use only, cannot be used for human consumption.

Pafuramidine Structure
Synonym:

DB289

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Quality Control & Documentation
Biological Activity

Pafuramidine (DB289) is an orally active proagent of Furamidine. Pafuramidine is a potent anti-parasitic agent, can be used to research trypanosomiasis, Pneumocystis pneumonia and malaria.

Chemical Information
Molecular Weight 364.4
Formula C20H20N4O3
CAS Number 186953-56-0
Form Solid
Solubility (25°C) DMSO 33.33 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Myaing M Nyunt, et al. Am J Trop Med Hyg. Phase I/II evaluation of the prophylactic antimalarial activity of pafuramidine in healthy volunteers challenged with Plasmodium falciparum sporozoites

[2] Donald Chen, et al. Expert Rev Anti Infect Ther. Pafuramidine for Pneumocystis jiroveci pneumonia in HIV-infected individuals

[3] Michael Zhuo Wang, et al. Drug Metab Dispos. Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine

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Keywords: Pafuramidine, DB289 supplier, Parasite, inhibitors, activators

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