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Paederosidic acid Methyl ester, an ATP-sensitive K+ Channel activator, was isolated from P. scandens. Paederosidic acid Methyl ester has shown significant central pain-relieving activity, increasing pain thresholds by activating ATP-sensitive K+ channels in the brain and spinal cord levels.
| Molecular Weight | 478.47 |
| Formula | C19H26O12S |
| CAS Number | 122413-01-8 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Xu Zou, et al. Studies on chemical constituents of Paederia scandense
| Related Potassium Channel Products |
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| TAK-438
TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| ML133 hydrochloride
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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