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Pactimibe (CS-505) free base is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505) free base inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe (CS-505) free base noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe (CS-505) free base obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe (CS-505) free base possesses anti-atherosclerotic potential with lowering plasma cholesterol activity.
| Molecular Weight | 416.6 |
| Formula | C25H40N2O3 |
| CAS Number | 189198-30-9 |
| Form | Solid |
| Solubility (25°C) | DMSO 120 mg/mL (ultrasonic) |
| Storage | 4°C, dry, sealed |
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