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Pabinafusp alfa

Cat. No. M24945

All AbMole products are for research use only, cannot be used for human consumption.

Pabinafusp alfa Structure
Synonym:

JR-141

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Quality Control & Documentation
Biological Activity

Pabinafusp alfa (JR-141) is a transferrin receptor-targeting antibody consisting of Iduronate 2-sulfatase and an anti-human transferrin receptor antibody. Pabinafusp alfa is blood-brain permeable and prevents heparan sulfate (HS) deposition in the central nervous system of mucopolysaccharidosis II (MPS II) mice. Pabinafusp alfa improves learning and prevents central nervous system neuronal damage in mice.

Chemical Information
CAS Number 2140211-48-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Hélène Kaplon, et al. MAbs. Antibodies to watch in 2022

[2] Ryuji Yamamoto, et al. Mol Genet Metab Rep. Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II

[3] Roberto Giugliani, et al. Mol Ther. Iduronate-2-sulfatase fused with anti-hTfR antibody, pabinafusp alfa, for MPS-II: A phase 2 trial in Brazil

[4] Torayuki Okuyama, et al. Mol Ther. A Phase 2/3 Trial of Pabinafusp Alfa, IDS Fused with Anti-Human Transferrin Receptor Antibody, Targeting Neurodegeneration in MPS-II

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Keywords: Pabinafusp alfa, JR-141 supplier, inhibitors, activators

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