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PA-8 

Cat. No. M30790

All AbMole products are for research use only, cannot be used for human consumption.

PA-8  Structure

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Quality Control & Documentation
Biological Activity

PA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM.

Chemical Information
Molecular Weight 342.35
Formula C17H18N4O4
CAS Number 878437-15-1
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Majid Neamah Ali, et al. Polim Med. Extracellular product of Pseudomonas aeruginosa in growth medium is involved in the pro-inflammatory cytokine response of human oral epithelial cells in vitro

[2] Ichiro Takasaki, et al. Eur J Med Chem. Design and synthesis of pyrido[2,3-d]pyrimidine derivatives for a novel PAC1 receptor antagonist

[3] Adam M Gonzalez, et al. Appl Physiol Nutr Metab. Effects of phosphatidic acid supplementation on muscle thickness and strength in resistance-trained men

[4] Mary Amanda Dew, et al. Transplantation. Depression and Anxiety as Risk Factors for Morbidity and Mortality After Organ Transplantation: A Systematic Review and Meta-Analysis

[5] R Yoshimura, et al. Jpn J Cancer Res. Immunohistochemistry of human gastrointestinal cancer-associated antigen detected by monoclonal antibody PA 8-15

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Keywords: PA-8  supplier, inhibitors, activators

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