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p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.
| Molecular Weight | 349.35 |
| CAS Number | 1006378-90-0 |
| Solubility (25°C) | DMSO 8.33 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Joseph M Grimes, et al. p38 MAPK inhibition: A promising therapeutic approach for COVID-19
[2] Ana Cuadrado, et al. Mechanisms and functions of p38 MAPK signalling
[4] Lydia R Coulthard, et al. p38(MAPK): stress responses from molecular mechanisms to therapeutics
[5] Tyler Zarubin, et al. Activation and signaling of the p38 MAP kinase pathway
| Related p38 MAPK Products |
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BIRB 796 (Doramapimod) is a protein kinase inhibitor of p38 MAPK with Kd of 100pM. |
| Selonsertib
GS-4997 is a highly selective and potent once-daily oral ASK1 inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. |
| Adezmapimod
Adezmapimod (SB203580) is a P38 MAPK inhibitor with an IC50 of 0.3-0.5 μM, which is 10 times less selective than SAPK3(106T) and SAPK4(106T), and inhibits PKB phosphorylation with an IC50 of 3-5 μM. |
| SB 202190
SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase with IC50 values of 50 and 100 nM inhibiting p38α and p38β, respectively. |
| PH-797804
PH-797804 is a highly selective and potent inhibitor of p38 MAP kinase with IC50 of 26 nM. |
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