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P053 is a potent, non-competitive and selective ceramide synthase 1 (CerS1) inhibitor wirh an IC50 of 0.5 μM. P053 also acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle.
P053 (5 mg/kg; administered daily by oral gavage; 7 days) reduces C18 ceramide levels in skeletal muscle (SkM) in male C57BL6/J mice.
| Molecular Weight | 354.27 |
| Formula | C18H21Cl2NO2 |
| CAS Number | 2748196-63-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 60 mg/mL DMF 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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