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ORM-3819

Cat. No. M8713

All AbMole products are for research use only, cannot be used for human consumption.

ORM-3819 Structure

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Quality Control & Documentation
Biological Activity

Orm-3819 is a potent muscular compound that binds to cardiac troponin C (cTnC) and sensitizes the heart to Ca2+. Orm-3819 is also a selective and potent inhibitor of PDE III. Orm-3819 exhibits positive inotropic effects through Ca2+ sensitization and selective inhibition of PDE III. ORM-3819 is an effective myocardial block model in animals.

Chemical Information
Molecular Weight 397.38
Formula C19H19N5O5
CAS Number 360794-85-0
Solubility (25°C) DMSO: 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] No authors listed. J Cardiovasc Pharmacol. The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation: Erratum

[2] Zoltn Mrton, et al. The Novel Inodilator ORM-3819 Relaxes Isolated Porcine Coronary Arteries: Role of Voltage-Gated Potassium Channel Activation

[3] Lszl Nagy, et al. ORM-3819 promotes cardiac contractility through Ca(2+) sensitization in combination with selective PDE III inhibition, a novel approach to inotropy

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Keywords: ORM-3819 supplier, inhibitors, activators

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