All AbMole products are for research use only, cannot be used for human consumption.
Orientin is a bioactive compound isolated from medicinal plants that effectively inhibits Sortase A activity with an IC50 of 50.44 ± 0.51 µM. It also inhibits APAP-induced oxidative damage and mitochondrial dysfunction in hepatocytes via Nrf2 and JNK/cytochrome c/caspase-3 signaling pathways. It has antioxidant, anti-inflammatory and anti-cancer activities.
Pharmacol Rep. 2020 Jan 24.
Inhibitory effects of orientin in mast cell-mediated allergic inflammation.
Orientin purchased from AbMole
| Molecular Weight | 448.38 |
| Formula | C21H20O11 |
| CAS Number | 28608-75-5 |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[5] Kit Ying Lam, et al. A Review on Medicinal Properties of Orientin
| Related Immunology/Inflammation Products |
|---|
| Laquinimod
Laquinimod (ABR-215062) is a new orally active immunoregulator effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. |
| Cyclosporine A
Cyclosporine A (CsA，Cyclosporin A) is an immunosuppressant that binds to cyclophilin and inhibits calcineurin with an IC50 of 7 nM. Cyclosporine A [CsA] binds to the cyclophilin 18 (Cyp18)-CsA complex. the Cyp18-CsA complex recruits calcium-regulated neurophosphatase (CaN), leading to the blocking of cytokine gene transcription in activated T cells. CsA is a highly specific inhibitor of T-cell activation. |
| Pimecrolimus
Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis. |
| Meloxicam
Meloxicam (Mobic) is a nonsteroidal anti-inflammatory agent with analgesic and fever reducer effects. |
| Mycophenolic acid
Mycophenolic acid is an immunosuppressant agent used to prevent rejection in organ transplantation. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
