All AbMole products are for research use only, cannot be used for human consumption.
Onx-0914 (PR-957) is a selective inhibitor of low molecular weight polypeptide 7 (LMP7), a chymotrypsin subunit of the immune proteasome. Onx-0914 blocks cytokine production and reduces the progression of experimental arthritis. Onx-0914 is a non-competitive irreversible inhibitor of mycobacterium proteasome (Ki=5.2 μM). Onx-0914 activates latent HIV-1 through HF-1-mediated p-TEFb activation.
Sci Rep. 2024 Aug 19;14(1):19135.
Triazine herbicide prometryn alters epoxide hydrolase activity and increases cytochrome P450 metabolites in murine livers via lipidomic profiling
ONX-0914 purchased from AbMole
Int. J. Mol. Sci. 2023 Oct 17;24(20), 15266.
Mitochondrial and Proteasome Dysfunction Occurs in the Hearts of Mice Treated with Triazine Herbicide Prometryn
ONX-0914 purchased from AbMole
Sci Rep. 2020 Feb 25;10(1):3386.
Gender-specific Changes in Energy Metabolism and Protein Degradation as Major Pathways Affected in Livers of Mice Treated With Ibuprofen
ONX-0914 purchased from AbMole
Mol Cell Proteomics. 2016 Mar 28.
Delineation of molecular pathways involved in cardiomyopathies caused by troponin T mutations.
ONX-0914 purchased from AbMole
2015 Mar.
Effects of the Ubiquitin Proteasome Inhibitor on Ion Channels in Left Ventricular Hypertrophy and Association of rs3807989 with Atrial Fibrillation
ONX-0914 purchased from AbMole
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Source | Mol Cell Protomics (2016). Figure 4.ONX-0914 (Cat. No. M2071, Abmole Bioscience) |
| Method | Immunoproteasome Activity Assays | |
| Cell Lines | ||
| Concentrations | 20μM | |
| Incubation Time | 60 min | |
| Results | Levels of ubiquitinated proteins in total homogenates and oxidized proteins in cytosolic homogenates (as determined using the OxyBlot procedure, which detects carbonylated proteins) were increased in I79N mice relative to WT and R278C mice, consistent with impaired UPS function. |
| Cell Experiment | |
|---|---|
| Cell lines | ALL and AML cells |
| Preparation method | MTT cytotoxicity assay Cytotoxicity of bortezomib, dexamethasone, as well as their combination, and carfilzomib, ONX 0912, ONX 0914, and 5AHQ was determined using the MTT colorimetric dye reduction assay. For the drug combination study, CalcuSyn (Version 1.1.1 1996, Biosoft, Cambridge, UK) software was used to calculate a combination index (CI) based on the median-effect principle, for each drug combination tested. |
| Concentrations | 0~1µM |
| Incubation time | 96h |
| Animal Experiment | |
|---|---|
| Animal models | RIP-GP mice model |
| Formulation | an aqueous solution of 10% (wt/vol) sulfobutylether-b-cyclodextrin and 10 mM sodium citrate (pH 3.5) |
| Dosages | 6 mg per kg body weight for 10 d |
| Administration | a single i.v. bolus |
| Molecular Weight | 580.67 |
| Formula | C31H40N4O7 |
| CAS Number | 960374-59-8 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Proteasome Products |
|---|
| Bortezomib (PS-341)
Bortezomib (PS-341) is a highly selective proteasome inhibitor with a ki value of 6nM. |
| CTP-518
CTP-518 is a novel HIV protease inhibitor. CTP-518 has the potential to be the first HIV protease inhibitor toeliminate the need to co-dose with a boosting agent. |
| ITMN-191
ITMN-191 (Danoprevir, RG7227) is a potent and orally active inhibitor of hepatitis C virus (HCV) NS3/4A serine protease with an IC50 of 1.6 nM. |
| MG132
MG132 is a specific and potent cell-permeable proteasome inhibitor (IC50 = 100 nM, Ki = 4 nM). MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132 is also a calpain inhibitor with IC50 of 1.2 μM. |
| IU1
IU1 is a reversible, small molecule inhibitor of deubiquitination by USP14 that demonstrates an IC50 value of 4-5 μM. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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