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Onjisaponin-B

Cat. No. M4190

All AbMole products are for research use only, cannot be used for human consumption.

Onjisaponin-B Structure
Size Price Availability Quantity
5mg USD 190 In stock
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Quality Control & Documentation
Biological Activity

Onjisaponin B isa natural product extracted from Polygonum. In PC-12 cells, Onjisaponin B can promote autophagy and accelerate the degradation of mutant α -synuclein and Huntington protein, which can be used to study Parkinson's disease and Huntington's disease.

Chemical Information
Molecular Weight 1573.67
Formula C75H112O35
CAS Number 35906-36-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fang Peng, et al. The onjisaponin B metabolite tenuifolin ameliorates dopaminergic neurodegeneration in a mouse model of Parkinson's disease

[2] Xinyu Li, et al. Onjisaponin B (OB) is Neuroprotective During Cognitive Loss Through Immune-mediated and SIRT1 Pathways

[3] Gaowen Li, et al. Onjisaponin B prevents cognitive impairment in a rat model of D-galactose-induced aging

[4] Xiaohang Li, et al. Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

[5] An-Guo Wu, et al. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells

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Keywords: Onjisaponin-B supplier, Autophagy, inhibitors, activators

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