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Omeprazole (H 16868) is a first-in-class proton pump inhibitor (PPI), used for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria. Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazol can be used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD), laryngopharyngeal reflux (LPR) and Zollinger–Ellison syndrome. Proton pump inhibitors may be associated with a greater risk of osteoporosis related fractures and Clostridium difficile-associated diarrhea. Proton pump inhibitors (especially omeprazole) have been associated with several cases of acute tubulointerstitial nephritis, an inflammation of the kidneys that often occurs as an adverse compound reaction.
| Molecular Weight | 345.42 |
| Formula | C17H19N3O3S |
| CAS Number | 73590-58-6 |
| Solubility (25°C) | DMSO 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Proton Pump Products |
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| Dexlansoprazole
Dexlansoprazole, the dextrorotatory enantiomer of lansoprazole, is a proton pump inhibitor (PPI) formulated to have dual delayed-release properties. |
| Tenatoprazole
Tenatoprazole is a procompound of the proton pump inhibitor (PPI) class, which inhibits proton transport with IC50 of 3.2 μM. |
| Esomeprazole Sodium
Esomeprazole Sodium is a sodium salt of esomeprazole that is a potent proton pump inhibitor with an IC50 of 0.076 mg/kg. |
| Esomeprazole Magnesium
Esomeprazole Magnesium is a proton pump inhibitor to reduce gastric acid secretion. |
| Rabeprazole Sodium
Rabeprazole is a frequently used second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. |
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