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ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ (Cav2.1) channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine.
| Cell Experiment | |
|---|---|
| Cell lines | Mouse frontal cortex, mouse spinal cord neurons |
| Preparation method | Following the establishment of baseline activity for 90 min, increasing concentrations of ω-agatoxin were administered to the perfusion medium for 30 min each to generate a concentration response curve for each network. For all neuronal networks, drug exposure was followed by a 1 h washout with fresh recording media perfused at a constant rate of 1 mL per minute to determine if the effects were reversible. |
| Concentrations | 10 nM, 50 nM, 100 nM, 200 nM |
| Incubation time | 30 min |
| Animal Experiment | |
|---|---|
| Animal models | Male SPF mice of ddY strain |
| Formulation | Physiological saline containing 0.1% BSA |
| Dosages | 1 and 3 mg/kg |
| Administration | ICV |
| Molecular Weight | 5202.25 |
| Formula | C217H360N68O60S10 |
| CAS Number | 145017-83-0 |
| Solubility (25°C) | Water |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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