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Olezarsen

Cat. No. M40956

All AbMole products are for research use only, cannot be used for human consumption.

Olezarsen Structure
Synonym:

ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx

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Quality Control & Documentation
Biological Activity

Olezarsen, an N-acetylgalactosamine (GalNAc)-suffixed antisense oligonucleotide (ASO) targeting hepatic APOC3 mRNA, inhibits the production of apolipoprotein C-III (apoC-III) and can be used in studies related to familial celiac sprue syndrome (FCS).

Chemical Information
CAS Number 2097587-83-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ioanna Gouni-Berthold et al. Curr Atheroscler Rep. Updates in Drug Treatment of Severe Hypertriglyceridemia

[2] Iveta Merćep et al. Pharmaceuticals (Basel). New Therapeutic Approaches in Treatment of Dyslipidaemia-A Narrative Review

[3] Isabel Shamsudeen et al. Expert Rev Clin Pharmacol. Safety and efficacy of therapies for chylomicronemia

[4] Jean-Claude Tardif et al. Eur Heart J. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk

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Keywords: Olezarsen, ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx supplier, inhibitors, activators

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