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Ogremorphin (OGM; GPR68-IN-1) is a G protein coupled sensor GPR68 inhibitor, with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells.
Ogremorphin (1-5 µM) reduced the upregulation of inflammatory cytokine/chemokine genes TNF-α, ICAM-1, VCAM-1, IL-6, IL-8, IL-1 β in Human pulmonary arterial endothelial cells (HPAECs).
Ogremorphin (10 μM) added to a 96 well microtiter plate (5 embryos/well) arranged with zebrafish fertilized eggs induced phenotypes encompassing a wavy notochord, abnormal pigmentation, craniofacial defects, ventral curvature, and a shortened body axis.
| Molecular Weight | 359.44 |
| Formula | C21H17N3OS |
| CAS Number | 352563-21-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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