All AbMole products are for research use only, cannot be used for human consumption.
Odanacatib (MK-0822) is a selective and reversible inhibitor of cathepsin K (CatK). The cathepsin K inhibitor odanacatib (MK-0822) was shown to increase bone mineral density (BMD) and maintained normal bone strength at the spine in ovariectomized (OVX) rhesus monkeys. Odanacatib increased femoral neck (FN) BMD by 11% and 15% (p < 0.07) and ultimate load by 25% (p < 0.05) and 30% (p < 0.01) versus vehicle. Moreover, Odanacatib stimulated long-term FN and PF periosteal BFR by 3.5-fold and 6-fold with the 30 mg/kg dose versus vehicle, respectively. Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys. Odanacatib was more selective than the published Cat K inhibitors balicatib and relacatib. Odanacatib (MK 0822) is currently in Phase II clinical trials.
Int J Biol Macromol. 2025 Sep 05; .
Cathepsin K and glycosaminoglycans differentially regulate matrix metalloproteinase activity in dentin under various pH conditions
Odanacatib purchased from AbMole
J Appl Oral Sci. 2023 May 8;31:e20220449.
Do matrix metalloproteinase and cathepsin K inhibitors work synergistically to reduce dentin erosion?
Odanacatib purchased from AbMole
| Molecular Weight | 525.56 |
| Formula | C25H27F4N3O3S |
| CAS Number | 603139-19-1 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cathepsin Products |
|---|
| N-Ethylmaleimide
N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. |
| Balicatib
Balicatib is a potent and selective inhibitor of cathepsin K; 10-100-fold more potent in cell-based enzyme occupancy assays than against cathepsin B, L, and S. |
| Aloxistatin
Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor. |
| Cathepsin Inhibitor 1
Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| Loxistatin Acid
Loxistatin Acid (E-64C), a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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