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OATD-01

Cat. No. M14748

All AbMole products are for research use only, cannot be used for human consumption.

OATD-01 Structure
Size Price Availability Quantity
5mg USD 145 In stock
10mg USD 242 In stock
25mg USD 440 In stock
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Quality Control & Documentation
Biological Activity

OATD-01 is a highly potent, first-in-class, orally active and selective chitinase inhibitor with low nanomolar activity toward CHIT1 (hCHIT1,IC50=23 nM). OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets. OATD-01 exhibits significant antifibrotic efficacy in vivo and can be used for pulmonary fibrosis (IPF) research.

Chemical Information
Molecular Weight 390.91
CAS Number 2088453-21-6
Solubility (25°C) DMSO 90 mg/mL
Storage -20°C, protect from light, sealed
References

[1] Piotr Sklepkiewicz, et al. Inhibition of CHIT1 as a novel therapeutic approach in idiopathic pulmonary fibrosis

[2] Robert Koralewski, et al. Discovery of OATD-01, a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis

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Keywords: OATD-01 supplier, inhibitors, activators

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