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NVS-ZP7-4 is a potent ZIP7 Inhibitor, which inhibits Notch signaling with IC50 of 0.13 uM in HES-Luc reporter gene assays, selectively induces apoptosis and ER stress. NVS-ZP7-4 altered zinc in the ER, and an analog of the compound photoaffinity labeled ZIP7 in cells. NVS-ZP7-4 can probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway.
| Molecular Weight | 501.62 |
| Formula | C28H28FN5OS |
| CAS Number | 2349367-89-9 |
| Solubility (25°C) | DMSO 100 mg/mL |
| Storage | -20°C, protect from light, sealed |
[1] Erin Nolin, et al. Nat Chem Biol. Discovery of a ZIP7 inhibitor from a Notch pathway screen
| Related Notch Products |
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FLI-06 is a novel inhibitor of Notch signaling with EC50 of 2.3 μM. |
| LY900009
LY900009 is a potent, first-in-class Notch inhibitor with IC50 of 0.27 nM. |
| Tangeretin
Tangeretin is a flavonoid from citrus fruit peels, and is also selected as a Notch-1 inhibitor, which plays an important role in anti-inflammatory responses and neuroprotective effects in several disease models. |
| IMR-1
IMR-1 is a first-in-class, cell-permeable inhibitor of the Notch transcription activation complex, with an IC50 of 26 μM. IMR-1 prevents Maml1 from recruiting to the Notch ternary complex (NTC) in chromatin, inhibits transcription of Notch target genes, and has antitumor activity. |
| CB-103
CB-103 is a first-in-class, orally active inhibitor of the Notch transcription activation complex. CB-103 inhibits Notch signaling in primary human T cell acute lymphoblastic leukemia and other Notch-dependent human tumor cell lines, and concomitantly induces cell cycle arrest and apoptosis. |
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