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NVP-DPP-728 dihydrochloride is a potent and selective dipeptidyl peptidase IV inhibitor. NVP-DPP-728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity. NVP-DPP-728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.
| Molecular Weight | 371.27 |
| Formula | C15H18N6O.2HCl |
| CAS Number | 247016-69-9 |
| Solubility (25°C) | Water ≥ 40 mg/mL |
| Storage | 2-8°C, dry, sealed |
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