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NVP-2 is an effective and selective ATP competitive cyclin-dependent kinase 9 (CDK9) probe that inhibits CDK9/CycT activity.IC50 The value is 0.514 nM. NVP-2 has inhibitory effects on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases, which IC50 The values are 0.584 μM, 0.706 μM, and 0.605 μM, respectively. NVP-2 induces apoptosis.
| Cell Experiment | |
|---|---|
| Cell lines | SILAC-labeled mESCs |
| Preparation method | SILAC-labeled mESCs were seeded onto a 245 mm square dish. After 2 days, the cells were treated either with DMSO (1:1,000; v/v) as a control, or the transcription inhibitors, 1 μg/ml ActD, 500 nM Trp, 100 nM NVP-2 for 2 h. |
| Concentrations | 100 nM |
| Incubation time | 2 h |
| Animal Experiment | |
|---|---|
| Animal models | C57BL/6J mice |
| Formulation | DMSO |
| Dosages | 5 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 513.07 |
| Formula | C27H37ClN6O2 |
| CAS Number | 1263373-43-8 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Martha Bustos, et al. Auton Neurosci. Nausea and vomiting of pregnancy - What's new?
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| PD 0332991 HCL
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