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Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite enantiomer Nutlin-3a.
| Molecular Weight | 581.49 |
| Formula | C30H30Cl2N4O4 |
| CAS Number | 675576-97-3 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Voon Yee-Lin, et al. Nutlin-3, A p53-Mdm2 Antagonist for Nasopharyngeal Carcinoma Treatment
[4] Jarno Drost, et al. Sequential cancer mutations in cultured human intestinal stem cells
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