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NTRC 0066-0 

Cat. No. M28913

All AbMole products are for research use only, cannot be used for human consumption.

NTRC 0066-0  Structure

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Quality Control & Documentation
Biological Activity

NTRC 0066-0 is a selective threonine tyrosine kinase (TTK) inhibitor (IC50=0.9 nM). NTRC 0066-0 can be used for the research of cancer.

Chemical Information
Molecular Weight 565.71
Formula C33H39N7O2
CAS Number 1817791-73-3
Form Solid
Solubility (25°C) DMSO 20.83 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Guido J R Zaman, et al. Mol Cancer Ther. TTK Inhibitors as a Targeted Therapy for CTNNB1 ( β-catenin) Mutant Cancers

[2] Joost C M Uitdehaag, et al. J Mol Biol. Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity

[3] Marion A A Libouban, et al. Oncotarget. Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

[4] A R R Maia, et al. Ann Oncol. Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model

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Keywords: NTRC 0066-0  supplier, inhibitors, activators

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