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NTP42 

Cat. No. M29143

All AbMole products are for research use only, cannot be used for human consumption.

NTP42  Structure

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Quality Control & Documentation
Biological Activity

NTP42 is a thromboxane A2 (TXA2) receptor antagonist with an IC50 of 3.278 nM for antagonizing T prostanoid receptor (TP)- mediated [Ca2+] mobilization following stimulation of cells with the alternative TP agonist U46619. NTP42 can be used for the treatment of pulmonary arterial hypertension (PAH).

Chemical Information
Molecular Weight 515.53
Formula C25H23F2N3O5S
CAS Number 2055599-51-2
Form Solid
Solubility (25°C) DMSO 31.25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Eamon P Mulvaney, et al. Front Cardiovasc Med. The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload

[2] Eamon P Mulvaney, et al. Eur J Pharmacol. Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension

[3] Eamon P Mulvaney, et al. BMC Pulm Med. NTP42, a novel antagonist of the thromboxane receptor, attenuates experimentally induced pulmonary arterial hypertension

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Keywords: NTP42  supplier, Prostaglandin Receptor, inhibitors, activators

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