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NT219 

Cat. No. M27918

All AbMole products are for research use only, cannot be used for human consumption.

NT219  Structure

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Quality Control & Documentation
Biological Activity

NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases.

Chemical Information
Molecular Weight 412.26
Formula C16H14BrNO5S
CAS Number 1198078-60-2
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage -20°C, protect from light, dry, sealed
References

[1] Lingling E, et al. Stem Cells Dev. Effect of Insulin on Bone Formation Ability of Rat Alveolar Bone Marrow Mesenchymal Stem Cells

[2] Adi Jacob Berger, et al. Nat Cancer. IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

[3] Xiaolan Yang, et al. Clin Exp Rheumatol. Modulation of miR-548m encoded by X chromosome on the PTEN pathway in systemic lupus erythematosus

[4] Lorna Moll, et al. FASEB J. The inhibition of IGF-1 signaling promotes proteostasis by enhancing protein aggregation and deposition

[5] Tayir El-Ami, et al. Aging Cell. A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity

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  Catalog
Abmole Inhibitor Catalog




Keywords: NT219  supplier, Insulin Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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