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NSC668394

Cat. No. M14747

All AbMole products are for research use only, cannot be used for human consumption.

NSC668394 Structure

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Biological Activity

NSC668394 is a potent ezrin (Thr567) phosphorylation inhibitor, with a Kd of 12.59 μM. NSC668394 inhibit ezrin T567 phosphorylation caused by PKCΙ primarily via their binding to ezrin. NSC668394 can be used to prevent tumor metastasis.

Chemical Information
Molecular Weight 452.1
CAS Number 382605-72-3
Solubility (25°C) DMSO 3 mg/mL (ultrasonic and warming and heat to 60°C)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jean Carlos Lipreri da Silva, et al. Comprehensive analysis of cytoskeleton regulatory genes identifies ezrin as a prognostic marker and molecular target in acute myeloid leukemia

[2] Austin Proudfit, et al. Pharmacologic Inhibition of Ezrin-Radixin-Moesin Phosphorylation is a Novel Therapeutic Strategy in Rhabdomyosarcoma

[3] Liuyun Gong, et al. Integrative, genome-wide association study identifies chemicals associated with common women's malignancies

[4] Rhiannon E Roberts, et al. Phagocytosis and Motility in Human Neutrophils is Competent but Compromised by Pharmacological Inhibition of Ezrin Phosphorylation

[5] Haydar elik, et al. Ezrin Inhibition Up-regulates Stress Response Gene Expression

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Keywords: NSC668394 supplier, inhibitors, activators

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