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NSC23925 is a specific Pgp1 inhibitor. It reverses MDR1 (Pgp1) but does not inhibit MRP or BCRP-mediated MDR. NSC23925 itself is not a substrate of Pgp1 but stimulates ATPase activity of Pgp, directly inhibiting the function of Pgp1 in a dose-dependent manner without altering the total expression level of Pgp1.
| Molecular Weight | 421.36 |
| Formula | C22H24N2O2 · 2HCl |
| CAS Number | 858474-14-3 |
| Solubility (25°C) | Water: 5 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Shirin Mollazadeh, et al. Structural and functional aspects of P-glycoprotein and its inhibitors
[4] X Yang, et al. Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925
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