Free shipping on all orders over $ 500

NS11394

Cat. No. M14219

All AbMole products are for research use only, cannot be used for human consumption.

NS11394 Structure
Size Price Availability Quantity
5mg USD 80 In stock
10mg USD 130 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?
Quality Control & Documentation
Biological Activity

NS11394 is an orally active and unique subtype-selective GABAA positive allosteric receptor (PAM), with a Ki of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABAA-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties.

Chemical Information
Molecular Weight 353.42
CAS Number 951650-22-9
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Christine Sprte, et al. The α2β3γ2 GABA A receptor preferring agonist NS11394 aggravates dystonia in the phenotypic dt sz model

[2] Gordon Munro, et al. GABA(A) receptor modulation: potential to deliver novel pain medicines?

[3] Martine Hofmann, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function

[4] N R Mirza, et al. NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile], a unique subtype-selective GABAA receptor positive allosteric modulator: in vitro actions, pharmacokinetic properties and in vivo anxiolytic efficacy

[5] G Munro, et al. Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with diazepam, zolpidem, bretazenil, and gaboxadol in rat models of inflammatory 䲧璵Ỵ璶㧀璴羹癦

Related GABA Receptor Products
SKF 89976A hydrochloride

SKF 89976A hydrochloride is a potent GABA uptake inhibitor, selective for GAT-1.
Alpidem

Alpidem is a potent antagonist of peripheral benzodiazepine receptor (PBR).
(R)-Baclofen

(R)-baclofen, a gamma-aminobutyric acid derivative and agonist at GABA-B receptors, inhibits nerve conduction in the central nervous system and can be used in studies related to spasticity.
(+)-Bicuculline

(+)-Bicuculline is a competitive antagonist of GABAA receptors with IC50 of 2 μM, also blocks Ca(2+)-activated potassium channels.
Bemegride

Bemegride is a central nervous system stimulant and antidote for barbiturate poisoning.
  Catalog
Abmole Inhibitor Catalog




Keywords: NS11394 supplier, GABA Receptor, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.