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NS 1738

Cat. No. M30193

All AbMole products are for research use only, cannot be used for human consumption.

NS 1738 Structure
Synonym:

NSC 213859

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Quality Control & Documentation
Biological Activity

NS 1738 (NSC 213859) is a novel positive allosteric modulator of the α7 nAChR, with respect to positive modulation of α7 nAChR (EC50=3.4 μM in oocyte experiments).

Chemical Information
Molecular Weight 365.13
Formula C14H9Cl2F3N2O2
CAS Number 501684-93-1
Form Solid
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Spencer R Pierce, et al. Biomolecules. Mutational Analysis of Anesthetic Binding Sites and Their Effects on GABAA Receptor Activation and Modulation by Positive Allosteric Modulators of the α7 Nicotinic Receptor

[2] Zsolt Kristóf Bali, et al. Sci Rep. Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo

[3] Kateryna Uspenska, et al. Int J Biochem Cell Biol. Positive allosteric modulators of α7* or β2* nicotinic acetylcholine receptors trigger different kinase pathways in mitochondria

[4] Katarzyna M Targowska-Duda, et al. J Biomol Struct Dyn. Molecular interactions of type I and type II positive allosteric modulators with the human α7 nicotinic acetylcholine receptor: an in silico study

[5] Guanglin Kuang, et al. Phys Chem Chem Phys. Theoretical study of the binding profile of an allosteric modulator NS-1738 with a chimera structure of the α7 nicotinic acetylcholine receptor

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Keywords: NS 1738, NSC 213859 supplier, AChR/AChE, inhibitors, activators

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