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NS-1619 induced concentration-dependent activation of BKCa channels with a calculated EC50 of 32 microM. The NS-1619-induced activity was dependent on the presence of free Ca2+ at the intracellular surface, but was not associated with a change in channel voltage sensitivity. NS-1619 (50 microM) inhibited the noradrenaline-induced contraction. NS-1619 (10-100 microM) reduced the high K+-induced contractions in a noncompetitive manner. NS-1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
| Molecular Weight | 362.23 |
| Formula | C15H8F6N2O2 |
| CAS Number | 153587-01-0 |
| Form | Solid |
| Solubility (25°C) | DMSO 24 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Lee K,et.al. Eur J Pharmacol. NS 1619 activates BKCa channel activity in rat cortical neurones.
| Related Potassium Channel Products |
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| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
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| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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