All AbMole products are for research use only, cannot be used for human consumption.
Novobiocin (Albamycin) is a potent and orally active antibiotic. Novobiocin also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin shows anti-orthopoxvirus activity.
Novobiocin (1 mM) competitively inhibits ATP binding to gyrase B to interfere with nucleotide binding and interferes with the association of the co-chaperones Hsc70 and p23 with Hsp90. Novobiocin (200 µM; 24 h) inhibits the rate of repair of both cis-DDP and BCNU induced DNA interstrand cross-links and with a corresponding decrease in the clonogenic survival of the human glioblastoma multiforme cells.
Novobiocin (25, 50, 100, 200 mg/kg; s.c.; 4 times at 1, 5, 24 and 48 h after infection) shows anti-infection activity in mice infected with amoxicillin-resistant Streptococcus pneumoniae.
| Molecular Weight | 612.62 |
| Formula | C31H36N2O11 |
| CAS Number | 303-81-1 |
| Solubility (25°C) | DMSO 31 mg/mL |
| Storage | -20°C, dry, sealed |
[1] Angelika Dlugosz, et al. Mini Rev Med Chem. Novobiocin Analogs as Potential Anticancer Agents
[3] H HOEKSEMA, et al. Prog Ind Microbiol. Novobiocin
[4] No authors listed. Q Rev Pediatr. NOVOBIOCIN
[5] H D Riley Jr. Med Clin North Am. Vancomycin and novobiocin
| Related Antibiotic Products |
|---|
| Kanamycin sulfate
Kanamycin sulfate is an aminoglycoside antibiotic that acts as a bacteriostatic agent by binding to the bacterial 30S ribosome. |
| Marbofloxacin
Marbofloxacin is a potent antibiotic of the 3rd generation fluoroquinolone group which inhibiting bacterial DNA replication. |
| Linezolid
Linezolid (PNU-100766) is a synthetic antibiotic. Linezolid acts by inhibiting the initiation of bacterial protein synthesis. |
| Daptomycin
Daptomycin is the first member of a new class of bactericidal antibiotics, the cyclic lipopeptides. |
| Sulfadimethoxine
Sulfadimethoxine (trade name Di-Methox, Albon) is a sulfonamide antibiotic. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
