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Nourseothricin is a broad-spectrum antibiotic derived from Streptomyces noursei. It has been also shown that nourseothricin was able to generate some channels into the outer membrane. Moreover, resistant strains containing a streptothricin-inactivating acetyl transferase exhibited an additional protecting system, namely a reduced penetrability of the outer membrane.
In vivo, animal study showed that nourseothricin was preferentially excreted via kidney and signs of nephrotoxicity could be seen.
| Molecular Weight | 1359.47 |
| Formula | C31H58N12O10.C19H34N8O8.H2SO4 |
| CAS Number | 96736-11-7 |
| Solubility (25°C) | Water 100 mg/mL |
| Storage | 2-8°C, dry, sealed |
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