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nor-NOHA acetate is a specific and reversible inhibitor of rat liver arginase. nor-NOHA could inhibit the proliferation and induce the apoptosis of HepG2 cells. nor-NOHA was also able to decrease the expression levels of Arg1 and MMP-2, increase the expression levels of P53 and ECD as well as the production of NO. In vivo, nor-NOHA treatment could fully restore the aortic response to Ach to that of healthy rats.
| Molecular Weight | 296.28 |
| Formula | C9H20N4O7 |
| CAS Number | 1140844-63-8 |
| Form | Solid |
| Solubility (25°C) | Water ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Arginase Products |
|---|
| BEC hydrochloride
BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively. |
| Arginase inhibitor 1
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively. |
| Nor NOHA hydrochlorate
Nor NOHA hydrochlorate is a specific and reversible inhibitor of arginase, which induces apoptosis in ARG2-expressing cells under hypoxic conditions. It has antileukemic activity. |
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