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Nolatrexed 2HCl, also known as AG337, is a thymidylate synthase inhibitor. Nolatrexed is a non-classical TS inhibitor in that it lacks a terminal glutamate side chain and is uncharged at physiological pH. Nolatrexed does not require a specific transport mechanism to enter into cells and, once within the cell, is not a substrate for the enzyme folyl polyglutamate synthetase.
In vivo, when nolatrexed was administered to nude mice bearing Bu25TK- tumor xenografts, a time-dependent increase in antitumor activity was observed.
| Molecular Weight | 357.26 |
| Formula | C14H14Cl2N4OS |
| CAS Number | 152946-68-4 |
| Form | Solid |
| Solubility (25°C) | DMSO: ≥ 16 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related DNA/RNA Synthesis Products |
|---|
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