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Nogalamycin is an anthracyclinone antibiotic. Nogalamycin is a potent antibiotic against Gram-positive bacteria, also has cytotoxicity against certain tumor cells. Nogalamycin is produced by Streptomyces nogalater var. Nogalater. Nogalamycin selectively inhibits RNA synthesis after binding to DNA template. Nogalamycin can be used for researching anticancer.
| Molecular Weight | 787.8 |
| Formula | C39H49NO16 |
| CAS Number | 1404-15-5 |
| Form | Solid |
| Storage | Powder -20°C |
[2] L D Williams, et al. Proc Natl Acad Sci U S A. Structure of nogalamycin bound to a DNA hexamer
[3] M Egli, et al. Biochemistry. DNA-nogalamycin interactions
[4] L H Li, et al. Pharmacol Ther. The biochemical pharmacology of nogalamycin and its derivatives
[5] P F Wiley, et al. J Am Chem Soc. Structure of nogalamycin
| Related DNA/RNA Synthesis Products |
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Clofarabine inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. |
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Gemcitabine (Gemzar, LY188011) inhibits DNA synthesis with an IC50 of 0.06 µM. |
| Nelarabine
Nelarabine is a novel purine antimetabolite antineoplastic agent. |
| Mizoribine
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. Mizoribine inhibits replication of SARS-CoV with IC50s of 3.5 μg/mL and 16 μg/mL for SARS-CoV Frankfurt-1 and SARS-CoV HKU39849, respectively. |
| Capecitabine
Capecitabine is an orally-administered chemotherapeutic agent. Capecitabine is a precursor, that is enzymatically converted to 5-fluorouracil in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. Capecitabine may inhibit cytochrome CYP2C9 enzyme, and therefore increase levels of substrates such as phenytoin and other substrates of CYP2C9. |
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