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NNZ-2591

Cat. No. M25421

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NNZ-2591 Structure

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Biological Activity

NNZ-2591 is a synthetic analogue of a small peptide of cyclic glycine proline (cGP). NNZ-2591 shows orally active and cross the blood-brain barrier. NNZ-2591 shows neuroprotective after ischemic brain injury.

NNZ-2591 (30 mg/kg; p.o.) prevented scopolamine-induced memory impairment in rats. NNZ-2591 (3 mg/kg; s.c.; daily for 5 days) completely preventes brain damage and significantly reduces the L/R ratio of time taken to touch to the patch at 5 d after injury in rats.

NNZ-2591 has the potential for the research of ischemic brain injury and angelman syndrome.

Chemical Information
Molecular Weight 194.23
Formula C10H14N2O2
CAS Number 847952-38-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jian Guan, et al. Recent Pat CNS Drug Discov. Insulin-like growth factor-1 and its derivatives: potential pharmaceutical application for treating neurological conditions

[2] Jian Guan, et al. Behav Brain Res. NNZ-2591, a novel diketopiperazine, prevented scopolamine-induced acute memory impairment in the adult rat

[3] Jian Guan, et al. Br J Pharmacol. IGF-1 derived small neuropeptides and analogues: a novel strategy for the development of pharmaceuticals for neurological conditions

[4] R V M Krishnamurthi, et al. Br J Pharmacol. A novel diketopiperazine improves functional recovery given after the onset of 6-OHDA-induced motor deficit in rats

[5] J Guan, et al. Neuropharmacology. Peripheral administration of a novel diketopiperazine, NNZ 2591, prevents brain injury and improves somatosensory-motor function following hypoxia-ischemia in adult rats

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