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NLRP3/AIM2-IN-2

Cat. No. M45373

All AbMole products are for research use only, cannot be used for human consumption.

NLRP3/AIM2-IN-2 Structure
Size Price Availability Quantity
5mg USD 55 In stock
10mg USD 90 In stock
25mg USD 175 In stock
50mg USD 270 In stock
100mg USD 400 In stock
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Quality Control & Documentation
Biological Activity

NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome-dependent cellular pyroptosis, with an IC50 value of 0.2392 ± 0.0233 μM.

Chemical Information
Molecular Weight 257.28
Formula C15H15NO3
CAS Number 791840-86-3
Form Solid
Solubility (25°C) DMSO >100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jianing Fu, et al. Annu Rev Immunol. Structural Mechanisms of NLRP3 Inflammasome Assembly and Activation

[2] Cong-Yuan Xia, et al. Pharmacol Res. The NLRP3 inflammasome in depression: Potential mechanisms and therapies

[3] Chunyuan Zhao, et al. Front Immunol. NLRP3 Inflammasome-A Key Player in Antiviral Responses

[4] Qinyu Wang, et al. Br J Pharmacol. Naringenin attenuates non-alcoholic fatty liver disease by down-regulating the NLRP3/NF-κB pathway in mice

[5] Matthew S J Mangan, et al. Nat Rev Drug Discov. Targeting the NLRP3 inflammasome in inflammatory diseases

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Keywords: NLRP3/AIM2-IN-2 supplier, NLR, inhibitors, activators

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