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NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 can inhibit acute rejection of orthotopic lung allograft in rats by inhibiting proliferation in vivo.
| Molecular Weight | 546.1 |
| Formula | C27H43NO8.HCl |
| CAS Number | 138605-00-2 |
| Solubility (25°C) | Water 21.84 mg/mL |
| Storage | 4°C, dry, sealed |
| Related Adenylate Cyclase Products |
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| Forskolin
Forskolin is a diterpenoid natural product extracted from the hairy throat sphagnum flower (Coleus forskohlii), and is also a eukaryotic adenylate cyclase (AC) activator, which can increase cAMP levels. In addition, Forskolin can be used as a substitute for Oct4 in the induction and maintenance of pluripotent stem cells in mice and promotes osteoblast differentiation in vitro with potential anti-osteoporotic activity. |
| Bithionol
Bithionol is a potent inhibitor of soluble adenylyl cyclase(sAC) and has antibacterial and anthelmintic properties along with algaecide activity. |
| SQ22536
SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets. |
| KH7
KH7 is a specific inhibitor of soluble adenylate cyclase (sAC) with IC50 values of 3-10 μM against recombinant sACt proteins (human and others) in cells. KH7 is also an inhibitor of cAMP. |
| ST034307
ST034307 is a selective inhibitor of adenylyl cyclase 1 (AC1) with IC50 of 2.3 μM, it has analgesic activity. |
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