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NITD-916 

Cat. No. M28689

All AbMole products are for research use only, cannot be used for human consumption.

NITD-916  Structure

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Quality Control & Documentation
Biological Activity

NITD-916, a 4-hydroxy-2-pyridone derivative, is an orally active and highly lipophilic mycobacterial enoyl reductase InhA inhibitor with an IC50 of 570 nM. NITD-916 forms a ternary complex with InhA and NADH to block access to the fatty acyl substrate binding pocket. NITD-916 has potent anti-tuberculosis effects.

Chemical Information
Molecular Weight 311.42
Formula C20H25NO2
CAS Number 1614262-83-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Lindsay Flint, et al. PLoS One. InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis

[2] Matthéo Alcaraz, et al. ACS Infect Dis. Efficacy and Mode of Action of a Direct Inhibitor of Mycobacterium abscessus InhA

[3] Matthew B McNeil, et al. Tuberculosis (Edinb). Corrigendum to "Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA" [Tuberculosis 107 (December 2017) 133-136]

[4] Françoise Roquet-Banères, et al. Antimicrob Agents Chemother. In Vitro and In Vivo Efficacy of NITD-916 against Mycobacterium fortuitum

[5] Matthew B McNeil, et al. Tuberculosis (Edinb). Mechanisms of resistance against NITD-916, a direct inhibitor of Mycobacterium tuberculosis InhA

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Abmole Inhibitor Catalog




Keywords: NITD-916  supplier, Antibiotic, inhibitors, activators

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