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NITD008 is a selective flavivirus inhibitor. Adenosine analog. NITD008 inhibits dengue virus (EC50 = 0.64 μM), hepatitis C virus and cellular entry of Zika virus. NITD008 reduces increases of cytokines and NS1 and prevents death in dengue-infected mice. Active in vivo. Orally bioavailable.
| Molecular Weight | 290.27 |
| Formula | C13H14N4O4 |
| CAS Number | 1044589-82-3 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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