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Nisoldipine (Sular) is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, it relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload . [1, 2]
| Cell Experiment | |
|---|---|
| Cell lines | Ventricular myocytes |
| Preparation method | Bathing the myocytes in normal Tyrode's solution, held at -80 mV, and depolarised after 200-ms prepulses (-40mV) to more positive potentials for 500 ms at 0.1 Hz, recording tail currents on repolarisations to -40mV. Exposing the myocytes to 10-100 mM Nisoldipine for 8-10 minutes. Then using an EPC-7 amplifier to record the whole-cell membrane currents. |
| Concentrations | Dissolved in DMSO, final concentration 10-100 μM |
| Incubation time | 8-10 minutes |
| Animal Experiment | |
|---|---|
| Animal models | Male Wistar rats with chronic intragastric ethanol exposure |
| Formulation | Dissolved in DMSO and diluted in saline |
| Dosages | 10 mg/kg |
| Administration | Oral every day |
| Molecular Weight | 388.41 |
| Formula | C20H24N2O6 |
| CAS Number | 63675-72-9 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] R Heinig. Clinical pharmacokinetics of nisoldipine coat-core
| Related Calcium Channel Products |
|---|
| KB-R7943 mesylate
KB-R7943 mesylate is a potent, selective inhibitor of the reverse mode of the Na+/Ca2+ exchanger (IC50 = 0.7 mM). |
| Cilnidipine
Cilnidipine is a dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. |
| Azelnidipine
Azelnidipine is a novel dihydropyridine derivative, a L-type calcium channel blocker, and an antihypertensive. Azelnidipine inhibits the intracellular calcium ion flow and lower blood pressure by selectively blocking L-type calcium channel on the membrane of vascular smooth muscle. Azelnidipine inhibits esophageal squamous cell carcinoma proliferation by targeting MEK1/2. Azelnidipine also has anti-inflammatory, antioxidant and neuroprotective effects. |
| Catharanthine
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM |
| Cinepazide maleate
Cinepazide maleate is a maleate salt form of cinepazide which is a vasodilator. |
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