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Ninerafaxstat trihydrochloride shifts cellular metabolism to glucose oxidation from fatty acid oxidation. Ninerafaxstat trihydrochloride improves overall mitochondrial respiration and reduces fatty acid oxidation, thereby inhibiting the proliferation and growth of cancer cells. Ninerafaxstat trihydrochloride increases myocardial metabolic efficiency by shifting substrate utilization towards glucose through reducing fatty acid oxidation (inhibiting 3-ketoacyl CoA thiolase).
| Molecular Weight | 524.87 |
| Formula | C22H32Cl3N3O5 |
| CAS Number | 2311824-72-1 |
| Solubility (25°C) | DMSO 40 mg/mL |
| Storage | 4°C, dry, sealed |
[5] Z Darzynkiewicz, et al. Curr Protoc Cell Biol. Determining cell cycle stages by flow cytometry
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