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NID-1

Cat. No. M8457

All AbMole products are for research use only, cannot be used for human consumption.

NID-1 Structure

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Biological Activity

NID-1 (Novel Inducer of Death-1) is a cell permeable and potent inducer of energy-dependent non-apoptotic cell death in mammalian cell lines. NID-1 induced cell death is distinct from macroautophagy, but still reacquires ATG5 and the lysosomal hydrolase cathepsin-L.

Chemical Information
Molecular Weight 302.35
Formula C15H14N2O3S
CAS Number 476316-58-2
Solubility (25°C) DMSO: 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Kanae Matsuo, et al. Visualization of endogenous NID-1 and EMB-9 in C. elegans

[2] Kevin Celestrin, et al. Four specific immunoglobulin domains in UNC-52/Perlecan function with NID-1/Nidogen during dendrite morphogenesis in Caenorhabditis elegans

[3] Juliette Sage, et al. Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners

[4] Kurako Kidokoro, et al. Non-susceptibility genes to Bombyx densovirus type 1, Nid-1 and nsd-1, affect distinct steps of the viral infection pathway

[5] Agnieszka Trzebiatowska, et al. Caenorhabditis elegans teneurin, ten-1, is required for gonadal and pharyngeal basement membrane integrity and acts redundantly with integrin ina-1 and dystroglycan dgn-1

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Keywords: NID-1 supplier, inhibitors, activators

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