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(-)-Nicotine ditartrate

Cat. No. M2882

All AbMole products are for research use only, cannot be used for human consumption.

(-)-Nicotine ditartrate Structure
Size Price Availability Quantity
10mg USD 68 In stock
50mg USD 135 In stock
100mg USD 220 In stock
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Biological Activity

(-)-Nicotine ditartrate is a potent nicotinic acetylcholine receptor (nAChR) agonist. Stimulates autonomic ganglia and skeletal muscle neuromuscular junctions. Nicotine reduces beta-amyloidosis in a mouse model of Alzheimer's disease. (Ki values are 16.1 (α4β2), 2110 (α7), 520 (α3β4), 270 (α6/α4β4) and 2090 nM (α1β1γδ)).

Product Citations
Chemical Information
Molecular Weight 462.4
Formula C10H14N2.2C4H6O6
CAS Number 65-31-6
Solubility (25°C) Soluble in water to 100 mM
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Baeksun Kim, et al. Behav Brain Funct. Behavioral characterization of early nicotine withdrawal in the mouse: a potential model of acute dependence

[2] Claudio Coddou, et al. Philos Trans R Soc Lond B Biol Sci. Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice

[3] Coolon RA, et al. Behav Pharmacol. Individual differences in response to novelty and the conditioned locomotor effects of nicotine.

[4] Benowitz NL. Annu Rev Pharmacol Toxicol. Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.

[5] Nordberg A, et al. J Neurochem. Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw).

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