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Nicotinamide riboside chloride is an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside Chloride is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside blocks degeneration of surgically severed dorsal root ganglion neurons ex vivo and protects against noise-induced hearing loss in living mice. Nicotinamide riboside prevents muscle, neural and melanocyte stem cell senescence. Increased muscular regeneration in mice has been observed after treatment with nicotinamide riboside, leading to speculation that it might improve regeneration of organs such as the liver, kidney, and heart. Nicotinamide riboside also lowers blood glucose and fatty liver in prediabetic and type 2 diabetic models while preventing the development of diabetic peripheral neuropathy.
Nat Metab. 2026 Jan;8:62-73.
The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans
Nicotinamide riboside chloride purchased from AbMole
| Molecular Weight | 290.7 |
| Formula | C11H15ClN2O5 |
| CAS Number | 23111-00-4 |
| Solubility (25°C) | Water ≥ 90 mg/mL DMSO 50 mg/mL |
| Storage | 2-8°C, protect from light, sealed |
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