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Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain.
| Molecular Weight | 211.17 |
| Formula | C8H9N3O4 |
| CAS Number | 65141-46-0 |
| Solubility (25°C) | DMSO 30 mg/mL Water 18 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Hend Ashour, et al. Hypothesis: The potential therapeutic role of nicorandil in COVID-19
[4] Mustafa Karanfil, et al. Nicorandil and Contrast-Induced Nephropathy
| Related Potassium Channel Products |
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| TAK-438
TAK-438 is a novel and potent potassium-competitive acid blocker (P-CAB) with IC50 of 19 nM. |
| ML133 hydrochloride
ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. |
| Doxapram hydrochloride hydrate
Doxapram hydrochloride hydrate inhibits TASK-1, TASK-3, TASK-1/TASK-3 heterodimeric channel function with EC50 of 410 nM, 37 μM, 9 μM, respectively. |
| Gliquidone
Gliquidone is an ATP-sensitive K+ channel antagonist with IC50 of 27.2 nM. |
| Pinacidil monohydrate
Pinacidil monohydrate is known to augment a time-independent outward current in cardiac tissues by activating the ATP-regulated potassium channels. |
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