All AbMole products are for research use only, cannot be used for human consumption.
NGP 555 has very good brain penetration/absorption, distribution, metabolism, and excretion (ADME) properties. It efficiently crosses the blood-brain barrier, has a brain:plasma ratio of 0.93 (in Tg2576 mice) and shows in vivo efficacy for lowering the biomarker Aβ42 in rodent studies for brain and plasma. Chronic administration of NGP 555 (milled into chow) to Tg2576 mice results in a significant reduction of amyloid plaques.
| Cell Experiment | |
|---|---|
| Cell lines | SH-SY5Y-APP cells |
| Preparation method | SH-SY5Y-APP cells are treated with various concentrations of NGP 555 or NGP 328, in triplicate wells, for 18 hours. Media is collected and analyzed for Aβ peptides using Meso Scale triplex ELISA (Aβ38, Aβ40, and Aβ42) and total Aβ ELISA. |
| Concentrations | 10 nM-100 μM |
| Incubation time | 18 h |
| Animal Experiment | |
|---|---|
| Animal models | Sprague-Dawley male rats |
| Formulation | 80% PEG |
| Dosages | 0-37.5 mg/kg |
| Administration | oral administration |
| Molecular Weight | 406.52 |
| Formula | C23H23FN4S |
| CAS Number | 1304630-27-0 |
| Form | Solid |
| Solubility (25°C) | 10 mM in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Gamma-secretase/Beta-secretase Products |
|---|
| DAPT
DAPT (GSI-IX) is a γ-secretase inhibitor with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively. DAPT inhibits the activation of Notch 1 signaling. |
| BMS-708163
BMS-708163 (Avagacestat) is a selective γ-secretase inhibitor (IC50 = 0.3 nM). |
| RO4929097
RO4929097 is a potent and selective inhibitor of γ-secretase and as a result is able to inhibit Notch pathway signaling. |
| MK-0752
MK-0752 is a potent, oral inhibitor of γ-secretase with IC50 of 5 nM in human SH-SY5Y cells. |
| LY-411575
LY-411575 is potent and selective small molecule γ-secretase inhibitor with IC50 of 0.1 nM for APP23 and APP51/16 primary neurons. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2026 AbMole BioScience. All Rights Reserved.
