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NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p.
| Molecular Weight | 346.81 |
| CAS Number | 212779-48-1 |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] Seik Weng Ng. Acta Crystallogr Sect E Struct Rep Online. 2-Chloro-3-nitro-pyridine
[3] J C Nelson, et al. J Clin Endocrinol Metab. Serum diiodotyrosine
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