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NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM.
| Molecular Weight | 443.54 |
| CAS Number | 2380230-73-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL Water 4.55 mg/mL (ultrasonic and adjust pH to 9 with NaOH) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Succinate Receptor Products |
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Succinate/succinate receptor antagonist 1 is a succinate/succinate receptor antagonist. Succinate/succinate receptor antagonist 1 blocks succinate signaling in gingival tissue. Succinate/succinate receptor antagonist 1 inhibits the activation of succinate receptor 1 (SucnRl) with an IC50 value of 20 μΜ. |
| SUCNR1-IN-2
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